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Date Posted: 2/25/2015
Title: LifeExtension Foundation for Longer Life


Life Extension

Life Extension






Meta-analysis adds evidence to anti-inflammatory effect for vitamin E supplementation

Life Extension Update

This issue of Life Extension® Update reports the outcome of a meta-analysis of twelve clinical trials, which revealed a benefit for both the alpha and gamma tocopherol forms of vitamin E in reducing inflammation.

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What's Hot

Higher dietary antioxidant capacity associated with lower cardiovascular disease indicators

What's Hot



In an article published online on January 4, 2013 in the European Journal of Clinical Nutrition, researchers from the University of Connecticut report an association between improved dietary antioxidant capacity and reductions in plasma homocysteine and C-reactive protein (CRP), both of which are markers of increased cardiovascular disease risk.

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Life Extension Clinical Research Update

Participate in a Clinical Study:

Support blood sugar and blood vessel health (CL049)

South Florida Location

Study objective:

Assess the effectiveness of nutritional supplements to improve blood sugar and blood vessel health over the course of 90 days.

To Qualify:

  • You must be between 25 and 65 years of age.
  • Have mildly elevated blood sugar with no previous diagnosis of diabetes.
  • Be overweight (BMI of 25 - 34.9).

Your Involvement:

  • You will make 5 visits over 90 days.
  • You will receive the nutritional supplement to be studied, blood tests, and blood vessel health evaluations.
  • Upon successful completion of the trial you will be compensated for time and travel up to $250 plus a $100 Life Extension® gift card.

Register For This Study


Or call 1-866-517-4536 FREE

Referral Bonus Available: $100*

Life Extension Clinical Research, Inc. engages in cutting-edge clinical trials with the goal of extending the healthy human life span and defeating disease. Our clinical research is designed to explore the potential of innovative dietary supplements, pharmaceuticals, topicals (cosmetic), and medical devices.

*If you refer someone who enrolls in a study and completes their final visit with closeout procedures, you will be compensated the amount noted for the study.




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Health Concern

Chronic inflammation

Of the ten leading causes of mortality in the United States, chronic, low-level inflammation contributes to the pathogenesis of at least seven. These include heart disease, cancer, chronic lower respiratory disease, stroke, Alzheimer's disease, diabetes, and nephritis (Centers for Disease Control and Prevention 2011; Bastard et al. 2006; Cao 2011, Jha et al. 2009; Ferrucci et al. 2010; Glorieux et al. 2009; Kundu et al. 2008; Murphy 2012; Singh et al. 2011).

C-reactive protein (CRP) is an acute-phase protein, one of several proteins rapidly produced by the liver during an inflammatory response. Its primary goal in acute inflammation is to coat damaged cells to make them easier to recognize by other immune cells (Meyer 2010). CRP elevation above basal levels is not diagnostic on its own, as it can raise in several cancers, rheumatologic, gastrointestinal, and cardiovascular conditions, and infections (Windgassen et al. 2011). Elevation of CRP (as determined by a high-sensitivity CRP assay or hs-CRP) has a strong association with elevated risk of cardiovascular disease and stroke (Emerging Risk Factors Collaboration et al. 2010).

Vitamin E functions as an antioxidant in the body. Specifically, vitamin E is incorporated into low-density lipoprotein (LDL) particles and protects them against oxidative damage; it seems to guard against atherosclerosis via other mechanisms as well (Meydani 2001). The gamma-tocopherol form of vitamin E appears to complement the anti-inflammatory action of alpha-tocopherol. Gamma-tocopherol has been shown to inhibit COX-2 and attenuate IL-1β signaling (Jiang 2000; Sjoholm 2001). In a small clinical trial on subjects with metabolic syndrome, the combination of gamma-tocopherol and alpha-tocopherol effectively suppressed C-reactive protein and TNA-α levels compared to placebo (Devaraj 2008). In this study, the combination of both tocopherols performed better than either alone, prompting the investigators to remark "the combination of [alpha-tocopherol] and [gamma-tocopherol] supplementation appears to be superior to either supplementation alone on biomarkers of oxidative stress and inflammation and needs to be tested in prospective clinical trials..."

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Scientists suggest that combining fish oil and krill oil may provide enhanced support for cardiovascular health and the brain due to the different ways that fish oil and krill oil are taken up by our cells. Fish oil and krill oil share many important similarities, such as reducing levels of omega-6 relative to beneficial omega-3 fatty acids. Most Americans consume too many omega-6 polyunsaturated fatty acids and not enough omega-3s.

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Human studies suggest that omega-3 fatty acids from fish oil result in a more rapid uptake into plasma triglyceride and platelet phospholipids, which specifically benefit the cardiovascular system.

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Related Life Extension Magazine® Articles

Testing For C-reactive

Protein May Save Your Life

What Doctors Don't Know

about Inflammation

Life Extension Magazine

Life Extension Magazine


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